منابع مشابه
Revisiting Thymus Function
For centuries, the thymus has been an organ in search of a function. The fact that it is a large mass of tissue in infancy was not appreciated at the beginning of the twentieth Century, as autopsies performed in infants succumbing to fatal illnesses such as diphtheria, revealed a small thymus. This resulted from stress during the illness, but the small size of the thymus was thought to be the n...
متن کاملStudies on Thymus Function
The immune functions of neonatally thymectomized C3Hf mice exposed only temporarily to thymus function show a progressive decay with time in the absence of the thymus. The immune responses studied at different ages in the range of 100-600 days were: first-set rejection of H-2-compatible and incompatible skin allografts, second-set rejection of skin allografts, capacity of spleen cells to produc...
متن کاملRevisiting the notion of function
Functions play a central role in type theory, logic and computation. We describe how the notions of functionalisation (the way in which functions can be constructed) and instantiation (the process of applying a function to an argument) have been developed in the last century. We explain how both processes were implemented in Frege’s Begriffschrift, Russell’s Ramified Type Theory, and the λ-calc...
متن کاملGenetic Control of Thymus-derived Cell Function
Concanavalin A- or phytohemagglutinin-stimulated DNA synthetic responses of 1 million normal mouse spleen cells in vitro were significantly different among various inbred strains. BALB/cJ (H-2(d)) responded better than C57BL/6J (H-2(b)) spleen cells, and the responses of C3H/HeJ or AKR/J (both H-2(k)) cells were intermediate. These responses, measured as the increment in thymidine-(3)H incorpor...
متن کاملMechanisms of thymus medulla development and function.
The development of CD4(+) helper and CD8(+) cytotoxic T-cells expressing the αβ form of the T-cell receptor (αβTCR) takes place in the thymus, a primary lymphoid organ containing distinct cortical and medullary microenvironments. While the cortex represents a site of early T-cell precursor development, and the positive selection of CD4(+)8(+) thymocytes, the thymic medulla plays a key role in t...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2014
ISSN: 1664-3224
DOI: 10.3389/fimmu.2014.00411